Friday, 7 August 2015
Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
Research (Published online: 07-08-2015)
1. Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats - Ankit S. Prajapati, Sunant K. Raval, Suprita Sinha, Tapan N. Varia and Parimal H. Mashiyava
Veterinary World, 8(8): 937-940
Aim: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats.
Materials and Methods: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol.
Results: The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity.
Conclusion: We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.
Keywords: azaserine, pancreatic cancer, Phyllanthus amarus, serum biochemistry, Wistar rat.