Research (Published online: 03-02-2016)
2. Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats - K. Kavitha, A. Gopala Reddy, K. Kondal Reddy, C. S. V. Satish Kumar, G. Boobalan and K. Jayakanth
Veterinary World, 9(2): 118-122
doi: 10.14202/vetworld.2016.118-122
Aim: The objective of the study was to assess the effect of combination treatment of insulin, pioglitazone and synbiotic on streptozotocin (STZ)-induced diabetic rats.
Materials and Methods: Diabetes mellitus was induced chemically by intraperitoneal administration of STZ (40 mg/kg b.wt) to male Sprague-Dawley rats. The rats were divided randomly into six groups of six rats in each. Group 1 was maintained as a normal control. Group 2 was maintained as diabetic control; Group 3 was treated with insulin; Group 4 with insulin + synbiotic; Group 5 with insulin + pioglitazone; and Group 6 with insulin + synbiotic + pioglitazone. All the animals were treated for 60 days.
Results: Body weights, and concentration of reduced glutathione (GSH), and high-density lipoproteins cholesterol were significantly (p<0.05) reduced, whereas the concentration of blood glucose, total cholesterol, triglycerides, protein carbonyls and thiobarbituric acid reacting substances, and the activity of GSH peroxidase were significantly (p<0.05) elevated in Group 2 at the end of 8th week as compared to Group 1. The treatment Groups 3, 4, 5 and 6 revealed improvement in all the parameters, and the highest improvement was observed in combination Group 6.
Conclusion: From this study, it is concluded that combination of insulin, pioglitazone and synbiotic is useful in treating diabetes.
Keywords: diabetes, insulin, oxidative stress, pioglitazone, synbiotic.
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