Histological assessment of the efficiency of rabbit serum in healing skin wounds

Research (Published online: 28-10-2019)

19. Histological assessment of the efficiency of rabbit serum in healing skin wounds

Abeer Ahmed Majeed and Dhyaa Ab. Abood

Veterinary World, 12(10): 1650-1656

ABSTRACT

Aim: This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.

Materials and Methods: A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.

Results: Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.

Conclusion: The results indicated that rabbit's serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.

Keywords: healing, rabbits, serum, skin, wounds.