Laboratory animal models for esophageal cancer

Review (Published online: 11-11-2016)

10. Laboratory animal models for esophageal cancer - Dhanya Venugopalan Nair and A. Gopala Reddy

Veterinary World, 9(11): 1229-1232

   doi: 10.14202/vetworld.2016.1229-1232

Abstract

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The incidence of esophageal cancer is rapidly increasing especially in developing countries. The major risk factors include unhealthy lifestyle practices such as alcohol consumption, smoking, and chewing tobacco to name a few. Diagnosis at an advanced stage and poor prognosis make esophageal cancer one of the most lethal diseases. These factors have urged further research in understanding the pathophysiology of the disease. Animal models not only aid in understanding the molecular pathogenesis of esophageal cancer but also help in developing therapeutic interventions for the disease. This review throws light on the various recent laboratory animal models for esophageal cancer.

Keywords: animal model, cancer, esophagus, mice, rat.