Heat shock proteins: a therapeutic target worth to consider

Review (Published online: 13-01-2015)

10. Heat shock proteins: a therapeutic target worth to consider - Amita Dubey, K. S. Prajapati, Madhu Swamy and V. Pachauri

Veterinary World, 8(1): 46-51

   doi: 10.14202/vetworld.2015.46-51

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Abstract

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Heat shock proteins (HSPs) are the molecular chaperones, that are not only expressed during the normal growth process of cell cycle consecutively, but also get induced in cells during various stress conditions produced by cellular insult, environmental changes, temperature, infections, tumors etc. According to their molecular weight and functions, HSPs are divided into five major families. HSP90, HSP70, HSP60 and HSP100 are the most studied members of the family. Experimental studies have proved that overexpression and/or inhibition of HSPs play an important role in maintaining the tolerance and cell viability under above-described stress conditions. HSP90 is found to be a promising candidate for the diagnosis, prognosis and treatment of cancer. Similarly, HSP70, HSP60 and small HSPs experimentally and clinically have potential for the treatment of neurodegenerative disease, ischemia, cell death, autoimmunity, graft rejection, etc. In a way, exploring, the cytoprotective and immunoregulatory role of HSPs can open a new avenue for the drug discovery and treatment of critical diseases.

Keywords: heat shock protein, heat shock protein 70, heat shock protein 90, stress protein, small heat shock proteins.